Small molecule 3PO inhibits glycolysis but does not bind
to 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase-3
(PFKFB3)
6-Phosphofructo-2-kinase/fructose-2,6-bisphosphatase isoform 3 (PFKFB3) is a key enzyme of the glycolytic pathway, and it plays an essential role in angiogenesis. 3-(3-Pyridinyl)-1-(4-pyridinyl)-2-propen-1-one (3PO) is frequently used as a glycolysis inhibitor and is thought to inhibit...